In Silico modeling of immune-cardiovascular-endocrine interactions

The immune system provides an intricate, balanced response to combat the effects of inflammatory stimuli. It incorporates both positive and negative feedback from multiple physiological systems such as cardiovascular endocrine including mechanisms functioning on a variety time scales. They have been studied individually via scientific experiments using mathematical modeling. However, more analysis is needed study interactions between these three during event. We present first dynamical model studying immune, responses 2 ng/kg bolus dose endotoxin. calibrated experimental data two endotoxin challenge studies we use this investigate dosage, administration timing method. Our shows that most repercussions clear within 24 hours, but can linger for up 72 hours.